About 30 results found for searched term "TRP Channel" (0.081 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2591 | Icilin | TRP Channel |
| AG 3-5 | ||
| Icilin is a synthetic super-agonist of the transient receptor potential M8 (TRPM8) ion channel. | ||
| M3366 | Amiloride hydrochloride dihydrate | Sodium Channel |
| MK-870 hydrochloride dihydrate | ||
| Amiloride Hydrochloride Dihydrate (MK-870 Hydrochloride Dihydrate) is an inhibitor of epithelial sodium channel (ENaC) and urokinase-type plasminogen activator receptor (uTPA). Amiloride hydrochloride dihydrate is polycystin-2 (PC2; TRPP2) channel blocker. | ||
| M5205 | ML204 | Calcium Channel |
| ML204 is a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels. | ||
| M5301 | (E)-Cardamonin | NLR |
| Alpinetin chalcone | ||
| (E)-Cardamonin is a novel antagonist of hTRPA1 cation channel with an IC50 of 454 nM, Cardamonin alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway. | ||
| M6380 | A 967079 | TRP Channel |
| A 967079 is a selective TRPA1 channel blocker. | ||
| M6393 | AC 4 | TRP Channel |
| AC 4 is a photoswitchable TRPV1 channel blocker. | ||
| M6466 | AS 1269574 | GPR/FFAR |
| AS1269574 is a potent, orally active GPR119 agonist with an EC50 of 2.5 μM in HEK293 cells expressing human GPR119. AS1269574 activates the TRPA1 cation channel and stimulates glucagon-like peptide-1 (GLP-1) secretion. AS1269574 specifically induced pancreatic β cells to secrete glucose-dependent insulin only under high glucose conditions. AS1269574 has potential for type 2 diabetes research. | ||
| M6494 | BCTC | TRP Channel |
| BCTC is a tRPV1 antagonist. BCTC is also a potent and specific inhibitor of transient receptor potential cation channel subfamily M member 8 (TRPM8) in prostate cancer (PCa) DU145 cells. | ||
| M6705 | EIPA | TRP Channel |
| L593754; MH 12-43; Ethylisopropylamiloride | ||
| EIPA (L593754) is an orally active TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA also enhances autophagy by inhibiting Na+/H+-exchanger 3 (NHE3). | ||
| M6983 | ML SA1 | TRP Channel |
| ML SA1 is a activator of TRPML channels. | ||
| M7151 | Polygodial | Others |
| Polygodial is a tRPA1 channel activator; analgesic and antifungal. | ||
| M7247 | SAR7334 dihydrochloride | Others |
| SAR 7334 2HCl | ||
| SAR7334 dihydrochloride is a novel, highly potent and bioavailable inhibitor of TRPC6 channels, inhibiting TRPC6 currents with IC50 of 7.9 nM. | ||
| M7303 | SKF 96365 hydrochloride | TRP Channel |
| SKF-96365 hydrochloride is a potent TRP channel blocker and SOCE (store-operated Ca2+ entry) inhibitor. It also induces cell cycle arrest and apoptosis in colorectal cancer cells. | ||
| M7313 | SN 2 | Others |
| SN 2 is a selective TRPML3 channel activator. | ||
| M7387 | TCS 5861528 | TRP Channel |
| Chembridge-5861528 | ||
| TCS 5861528 (Chembridge-5861528) is a potent TRPA1 channel antagonist that antagonizes similarly allyl isothiocyanate- and 4-HNE-evoked TRPA1 responses, with IC50 values of 14.3 μM and 18.7 μM, respectively. | ||
| M7577 | ML-7 hydrochloride | Others |
| ML-7 HCl | ||
| ML-7 hydrochloride is a naphthalene sulphonamide derivative, potently inhibits MLCK (IC50=300 nM) and TRPC6 channel (IC50>10 μM). | ||
| M7603 | AP-18 | TRP Channel |
| AP18 | ||
| AP-18 is a selective TRPA1 channel blocker. AP-18 blocks activation of TRPA1 by 50 μM Cinnamaldehyde with an IC50 of 3.1 μM and 4.5 μM for human and mouse TRPA1, respectively. | ||
| M7816 | GSK1016790A | TRP Channel |
| GSK1016790A is a novel and potent TRPV4 channel agonist. | ||
| M7836 | Hyperforin | TRP Channel |
| Hyperforin is a transient receptor typical 6 (TRPC6) channel activator that regulates Ca2+ levels by activating Ca2+-transducing non-selective typical TRPC6 channels, with antidepressant and antitumor activities. In addition, Hyperforin modulates IL-17α secretion from γδ T cells and ameliorates Imiquimod-induced skin inflammation in psoriasis-like mice. | ||
| M8589 | MSP-3 | TRP Channel |
| MSP-3 is a Transient Receptor Potential Vanilloid Type-1 (TRPV1) channel agonist with antioxidant and neuroprotective activity. | ||
| M9089 | SAR7334 | Others |
| SAR7334 is a novel, highly potent and bioavailable inhibitor of TRPC6 channels. | ||
| M10039 | GsMTx4 | Peptides |
| GsMTx-4 | ||
| GsMTx4 is a spider venom peptide that selectively inhibits cation-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. | ||
| M10318 | AC1903 | TRP Channel |
| AC-1903 | ||
| AC1903 is a specific inhibitor of TRPC5 channel. | ||
| M10625 | GSK2193874 | TRP Channel |
| GSK-2193874; GSK2193874A | ||
| GSK2193874 is a first-in-class orally bioavailable potent antagonist of TRPV4 channels, blocking the influx of calcium induced by the TRPV4 agonist with IC50 values of 2, 5, and 40 nM. GSK2193874 is the first-in-class orally bioavailable TRPV4 inhibitor that demonstrated ability to improve pulmonary functions in a number of heart failure models. | ||
| M10841 | Mavatrep | TRP Channel |
| JNJ-39439335 | ||
| Mavatrep is an orally active TRPV1 antagonist with high affinity for the hTRPV1 channel, inhibits the binding of the TRPV1 agonist to [3H]-Resiniferatoxin (Ki=6.5 nM), and has a low effect on the enzymatic activity of CYP subtypes 3A4, 1A2, and 2D6. | ||
| M10927 | GFB-8438 | TRP Channel |
| GFB-8438 is a potent subtype selective TRPC5 inhibitor against hTRPC5 and hTRPC4 IC50 0.18 and 0.29 μM, respectively. GFB-8438 has good selectivity for TRPC6, other members of the TRP family, NaV1.5, and limited activity against hERG channels. Protective effect of GFB-8438 on mouse podocytes. | ||
| M11223 | TRPM4-IN-1 | TRP Channel |
| CBA, Compound 5, TRPM4 inhibitor 5 | ||
| Trpm4-in-1 (CBA) is an effective and selective cationic channel TRPM4 inhibitor with an IC50 of 1.5 μM. | ||
| M14278 | EIPA hydrochloride | TRP Channel |
| L593754 hydrochloride; MH 12-43 hydrochloride | ||
| EIPA hydrochloride (L593754 hydrochloride) is a TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA hydrochloride also inhibits Na+/H+-exchanger (NHE) and macropinocytosis. | ||
| M14280 | GSK2798745 | TRP Channel |
| GSK2798745 is a first-in-class, highly potent, selective, orally active transient receptor potential vanilloid 4 (TRPV4) ion channel blocker with IC50s of 1.8 and 1.6 nM for hTRPV4 and rTRPV4, respectively. | ||
| M14282 | ML204 hydrochloride | TRP Channel |
| ML204 hydrochloride is a novel, potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca2+ channels. | ||
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